<i>Cis</i> -Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer
Bibliographic record
Abstract
No AccessJournal of UrologyCLINICAL UROLOGY: Milestone in Urology1 Dec 2002Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer LAWRENCE H. EINHORN and M.D., F.A.C.P. JOHN DONOHUEM.D. LAWRENCE H. EINHORNLAWRENCE H. EINHORN and JOHN DONOHUEJOHN DONOHUE View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64147-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered inevaluable due to early death. This chemotherapy regimen produced 74% complete and 26% partial remissions. Furthermore, five patients with partial remission became disease-free after surgical removal of residual disease, producing an overall 85% disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable, although there were two drug-related deaths during this period. Thirty-eight of these patients remain alive and 32 remain alive and disease-free at 6+ to 30+ months. We believe this regimen represents a major advance in the management of patients with disseminated testicular cancer. References 1 : A statistical review of malignant testicular tumors based on the experience of the Ontario Cancer Foundation Clinics, 1938–1961. Can Med Assoc J1966; 94: 889. Medline, Google Scholar 2 : Treatment and prognosis in seminoma of the testis. J Urol1968; 99: 72. Link, Google Scholar 3 : Recurrent seminoma: management of late metastases, recurrence of a second primary tumor. Am J Roentgenol Radium Ther Nucl Med1960; 83: 25. Medline, Google Scholar 4 : Effects of combined drug therapy on metastatic cancer of the testis. JAMA1960; 174: 145. 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Link, Google Scholar Indianapolis, Indiana, From the Indiana University Medical Center; Indianapolis, Indiana.© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by Bielefeld E, Gonzalez A and DeBacker J (2021) Changing the time intervals between cisplatin cycles alter its ototoxic side effectHearing Research, 10.1016/j.heares.2021.108204, VOL. 404, (108204), Online publication date: 1-May-2021. Harrison R, Seiler B and Bielefeld E (2016) Ototoxicity of 12 mg/kg cisplatin in the Fischer 344/NHsd rat using multiple dosing strategiesAnti-Cancer Drugs, 10.1097/CAD.0000000000000395, VOL. 27, NO. 8, (780-786), Online publication date: 1-Sep-2016. Dolan M, Newbold K, Nagasubramanian R, Wu X, Ratain M, Cook E and Badner J (2004) Heritability and Linkage Analysis of Sensitivity to Cisplatin-Induced CytotoxicityCancer Research, 10.1158/0008-5472.CAN-04-0340, VOL. 64, NO. 12, (4353-4356), Online publication date: 15-Jun-2004. Volume 168Issue 6December 2002Page: 2368-2372 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.MetricsAuthor Information LAWRENCE H. EINHORN More articles by this author JOHN DONOHUE More articles by this author Expand All Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".