The Human Serum Metabolome
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Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
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- Teacher spread
- 0.172 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- PLoS ONE
- Topic
- Metabolomics and Mass Spectrometry Studies
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- National Institute for NanotechnologyPrevention of Organ FailureUniversity of Alberta
- Funders
- National Heart, Lung, and Blood InstituteCanadian Institutes of Health ResearchAgricultural Research ServiceNational Institutes of HealthUniversity of AlbertaGenome British ColumbiaGenome AlbertaMinistry of Advanced Education, Government of AlbertaU.S. Department of Agriculture
- Keywords
- MetabolomeMetabolomicsMetaboliteHuman diseaseHuman physiologyComputational biologyBiologyBioinformaticsBiochemistry
- Has abstract in OpenAlex
- yes