<i>Pseudomonas aeruginosa</i>: new insights into pathogenesis and host defenses
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- Teacher spread
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Abstract
Pseudomonas aeruginosa is a metabolically versatile bacterium that can cause a wide range of severe opportunistic infections in patients with serious underlying medical conditions. These infections are characterized by an intense neutrophilic response resulting in significant damage to host tissues and often exhibit resistance to antibiotics leading to mortality. Treatment of persistent infections is additionally hampered by adaptive resistance, due to the growth state of the bacterium in the patient including the microorganism's ability to grow as a biofilm. An array of P. aeruginosa virulence factors counteract host defences and can cause direct damage to host tissues or increase the bacterium's competitiveness. New prevention and treatment methods are urgently required to improve the outcome of patients with P. aeruginosa infections. This review describes the two main types of P. aeruginosa lung infections and provides an overview of the host response and how the genomic capacity of P. aeruginosa contributes to the pathogenesis and persistence of these infections.
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The record
- Venue
- Pathogens and Disease
- Topic
- Bacterial biofilms and quorum sensing
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of British Columbia
- Funders
- Canadian Institutes of Health Research
- Keywords
- Pseudomonas aeruginosaVirulenceBiofilmMicrobiologyBiologyPathogenesisHost (biology)AntibioticsBacteriaAntibiotic resistanceHost resistanceImmunologyGeneGenetics
- Has abstract in OpenAlex
- yes