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Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function

2006· review· en· 705 citations· W2071963896 on OpenAlex· 10.1016/j.freeradbiomed.2006.09.030

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Bench or experimentalTheoretical or conceptualNot applicable
Classifier consensus
Bench or experimentalTheoretical or conceptual
Teacher imitation scores

Codex

Bench or experimental0.298
Theoretical or conceptual0.039
Not applicable0.005
Meta-analysis0.002
Systematic review0.001
Other design0.001
Observational0.001
Research integrity0.000
Open science0.000
Randomized trial0.000
Metaresearch0.000
Case report0.000
Scholarly communication0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Bibliometrics0.000
Non-randomized trial0.000
Simulation or modelling0.000
Qualitative0.000

Gemma

Bench or experimental0.149
Not applicable0.094
Theoretical or conceptual0.054
Systematic review0.001
Observational0.001
Meta-analysis0.001
Science and technology studies0.000
Randomized trial0.000
Open science0.000
Non-randomized trial0.000
Research integrity0.000
Meta-epidemiology (broad)0.000
Case report0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Scholarly communication0.000
Metaresearch0.000
Qualitative0.000
Simulation or modelling0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.030
GPT teacher head0.287
Teacher spread
0.258 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

As a cornerstone of the innate immune response, neutrophils are the archetypical phagocytic cell; they actively seek out, ingest, and destroy pathogenic microorganisms. To achieve this essential role in host defense, neutrophils deploy a potent antimicrobial arsenal that includes oxidants, proteinases, and antimicrobial peptides. Importantly, oxidants produced by neutrophils, referred to in this article as reactive oxygen (ROS) and reactive nitrogen (RNS) species, have a dual function. On one ha…

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