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Record W2072167136 · doi:10.4103/1817-1737.94519

Personalized medicine for asthma: Are we there yet?

2012· article· en· W2072167136 on OpenAlexaff
AudreyH Poon, Qutayba Hamid

Bibliographic record

VenueAnnals of Thoracic Medicine · 2012
Typearticle
Languageen
FieldMedicine
TopicAsthma and respiratory diseases
Canadian institutionsMcGill University
Fundersnot available
KeywordsMedicineAsthmaWheezeNatural historyDiseasePopulationEosinophilicImmunologyIntensive care medicinePediatricsInternal medicinePathology

Abstract

fetched live from OpenAlex

Asthma has generally been defined as a chronic disorder of the lung, with variable airway obstruction, wheeze/cough, and an underlying inflammatory process. However, considerable heterogeneity exists within the population of patients with asthma-like symptoms. Clinically, asthma is being categorized into eosinophilic, neutrophilic, atopic, non-atopic, early onset, and late onset; and aspirin- or exercise-induced in cases with known triggers. [1] The disease is currently recognized as a complex condition with variable severity, natural history, and response to treatment. Treating asthma based on phenotypes that group observable characteristics, with no direct relationship to the disease mechanisms is suboptimal, given the variability in treatment response. Endotyping, which refers to defining subpopulations of a disease based on molecular mechanisms or treatment response has shown some success in designing a more effective treatment scheme.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.012
metaresearch head score (Gemma)0.019
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.017
Threshold uncertainty score0.062

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0120.019
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0010.001
Science and technology studies0.0020.005
Scholarly communication0.0070.012
Open science0.0020.004
Research integrity0.0070.016
Insufficient payload (model declined to judge)0.0170.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.153
GPT teacher head0.447
Teacher spread0.294 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2012
Admission routes1
Has abstractyes

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