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Record W2072272271 · doi:10.1038/srep01802

InterMOD: integrated data and tools for the unification of model organism research

2013· article· en· W2072272271 on OpenAlexaff
Julie Sullivan, Kalpana Karra, Sierra Moxon, Andrew Vallejos, Howie Motenko, J. D. Wong, J. Aleksić, Rama Balakrishnan, Gail Binkley, Todd Harris, Benjamin C. Hitz, Pushkala Jayaraman, Rachel Lyne, Steven B. Neuhauser, Christian Pich, Richard Smith, Quang M. Trinh, J. Michael Cherry, Joel E. Richardson, Lincoln Stein, Simon Twigger, Monte Westerfield, Elizabeth A. Worthey, Gos Micklem

Bibliographic record

VenueScientific Reports · 2013
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBiomedical Text Mining and Ontologies
Canadian institutionsOntario Institute for Cancer Research
FundersNational Human Genome Research InstituteNational Institutes of HealthWellcome Trust
KeywordsModel organismOrganismDECIPHERComputational biologyData scienceConsistency (knowledge bases)Function (biology)UnificationBiologyComputer scienceGenomicsGenomeGeneBioinformaticsEvolutionary biologyGenetics

Abstract

fetched live from OpenAlex

Model organisms are widely used for understanding basic biology, and have significantly contributed to the study of human disease. In recent years, genomic analysis has provided extensive evidence of widespread conservation of gene sequence and function amongst eukaryotes, allowing insights from model organisms to help decipher gene function in a wider range of species. The InterMOD consortium is developing an infrastructure based around the InterMine data warehouse system to integrate genomic and functional data from a number of key model organisms, leading the way to improved cross-species research. So far including budding yeast, nematode worm, fruit fly, zebrafish, rat and mouse, the project has set up data warehouses, synchronized data models, and created analysis tools and links between data from different species. The project unites a number of major model organism databases, improving both the consistency and accessibility of comparative research, to the benefit of the wider scientific community.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.030
metaresearch head score (Gemma)0.047
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.030
Threshold uncertainty score0.159

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0300.047
Meta-epidemiology (narrow)0.0030.003
Meta-epidemiology (broad)0.0030.006
Bibliometrics0.0160.014
Science and technology studies0.0020.002
Scholarly communication0.0100.015
Open science0.0090.018
Research integrity0.0030.006
Insufficient payload (model declined to judge)0.0150.009

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.163
GPT teacher head0.384
Teacher spread0.220 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations27
Published2013
Admission routes1
Has abstractyes

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