Optimization Methods for Total Marrow Irradiation using Intensity Modulated Radiation Therapy
Bibliographic record
Abstract
As part of the conditioning process to prepare the patient for the bone marrow transplant, the patient is treated with total marrow irradiation (TMI). The purpose of TMI is to eliminate the underlying disease and to suppress the recipient's immune systems, thus preventing rejection of new donor stem cells. Designing a treatment plan for TMI poses unique challenges that are not present in other forms of site-specific radiation therapy, for example, head-and-neck and prostate treatments. Specifically, the large site to be treated results in clinical treatments where the patient must be positioned far from the isocenter, as well as often repositioned during treatment, thus increasing uncertainty in delivered dose. Designing TMI treatments with intensity modulated radiation therapy (IMRT) will provide more accurate treatments that can spare healthy tissues while simultaneously delivering the prescribed radiation dose to the bones. To bring the patient closer to isocenter, beam orientation optimization (BOO) will be used to incorporate non-coplanar beams. This work will present and discuss in detail the difficulties presented by TMI treatment planning in conjunction with IMRT, as well as the difficulties posed by non-coplanar BOO.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.003 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".