Intramural coronary artery constrictor reactivity to thromboxane is higher in male than in female rats
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
BACKGROUND: The prevalence of cardiovascular disorders is higher among men than in age-matched women. This is probably related, in part, to gender-dependent differences in coronary function including thromboxane-A(2) (TXA(2)) sensitivity. This question has been examined only on major, epicardial coronaries. The intramural small arteries directly responsible for supplying the myocardial arterioles with blood have been hardly accessible for investigation, owing to difficulties in their preparation. Vasoconstrictor TXA(2) excess generated by platelets and the vascular wall may play an important role in coronary ischemic events. In the present study we tested the vasoconstrictor reactivity of intramural coronary arteries to TXA(2). METHODS: Secondary, intramural branches of the left anterior descendent coronary artery of Sprague-Dawley rats (diameter: 200 microm) were placed into a vessel chamber. TXA(2) vasoconstrictor reactivity was measured on the basis of pressure-diameter curves in normal Krebs-Ringer solution and after addition of TXA(2) receptor agonist. RESULTS: Vasoconstrictor response induced by TXA(2) agonist was twice as strong in males compared with females for the whole pressure range ( p < 0.001). CONCLUSIONS: A gender-dependent difference was demonstrated in TXA(2)-induced contraction of intramural coronary artery segments. In some pathologic situations the enhanced TXA(2) release from platelets and injured vascular wall may cause greater vasoconstriction of intramural coronary arteries in males than in females.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it