Assignment of the <i>T</i><sub>2</sub> components of amphibian peripheral nerve to their microanatomical compartments
Bibliographic record
Abstract
The proton transverse-relaxation spectrum of peripheral nerve has been reported to consist of three components arising from microanatomical water compartments within the nerve. The component with the shortest decay time has been consistently seen to be a result of the myelin. In this study, experiments were performed to reveal the microanatomical sources of the two longest-lived components. Transverse-relaxation spectra were repeatedly obtained from samples of sciatic nerve of Xenopus laevis, the African clawed frog. These samples were maintained in vitro in a perfusion chamber, allowing for "on-the-fly" changes in perfusate composition. The changes in composition involved the addition of either 10-mM Mn(2+) or 30-mM Gd-DTPA to the perfusate, or the replacement of H(2)O in the perfusate by D(2)O. The D(2)O experiments revealed that >98% of the signal attributed to the nerve resulted from exchangeable water. Following the introduction of a paramagnetic agent into the perfusate, it was found that the intermediate-lived component of the nerve T(2) spectra disappeared within 10-50 min. However, the shortest- and longest-lived components remained, experiencing much more gradual long-term changes. It was thus concluded that the intermediate-lived component corresponds to the interaxonal compartment of nerve tissue based upon its closer proximity to the outside environment of the nerve.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".