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Record W2076090601 · doi:10.1159/000171400

Gamma-Aminobutyric Acid and the Liver

2008· review· en· W2076090601 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDigestive Diseases · 2008
Typereview
Languageen
FieldAgricultural and Biological Sciences
TopicGABA and Rice Research
Canadian institutionsUniversity of Manitoba
Fundersnot available
KeywordsBicucullineMedicineGABAergicHepatic encephalopathyGABAA receptorAminobutyric acidgamma-Aminobutyric acidInternal medicineHepatocyteEndocrinologyNeurotransmitterPharmacologyReceptorBiologyBiochemistryCirrhosis

Abstract

fetched live from OpenAlex

Gamma-aminobutyric acid (GABA) is a potent amino acid neurotransmitter with various physiologic effects throughout the body. Over the past 40 years it has become evident that the mammalian liver contains high concentrations of GABA which are carefully regulated by a series of hepatic metabolic pathways and a specific sodium-dependent active transport system. It is also clear that the liver possesses sodium-independent, bicuculline-sensitive GABAA receptor sites which when innervated cause marked hyperpolarization of the hepatocyte transmembrane potential. Recent data suggest that extensive hepatic injury alters GABA homeostatic mechanisms which in turn may contribute to the pathogenesis of hepatic encephalopathy and systemic hypotension. There is also reason to believe that increased GABAergic activity may inhibit hepatic regeneration following partial hepatectomy in rats.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.998
Threshold uncertainty score0.311

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.055
GPT teacher head0.293
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it