Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions
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Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Concerns/Issues about Image;Investigation by Company/Institution;Investigation by Journal/Publisher;Unreliable Data;Unreliable Results and/or Conclusions;Upgrade/Update of Prior Notice(s);
- Date
- 1/9/2025 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Mitotic cells inactivate DNA double-strand break (DSB) repair, but the rationale behind this suppression remains unknown. Here, we unravel how mitosis blocks DSB repair and determine the consequences of repair reactivation. Mitotic kinases phosphorylate the E3 ubiquitin ligase RNF8 and the nonhomologous end joining factor 53BP1 to inhibit their recruitment to DSB-flanking chromatin. Restoration of RNF8 and 53BP1 accumulation at mitotic DSB sites activates DNA repair but is, paradoxically, deleterious. Aberrantly controlled mitotic DSB repair leads to Aurora B kinase-dependent sister telomere fusions that produce dicentric chromosomes and aneuploidy, especially in the presence of exogenous genotoxic stress. We conclude that the capacity of mitotic DSB repair to destabilize the genome explains the necessity for its suppression during mitosis, principally due to the fusogenic potential of mitotic telomeres.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Science
- Topic
- DNA Repair Mechanisms
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of TorontoLunenfeld-Tanenbaum Research InstituteMount Sinai Hospital
- Funders
- Canadian Institutes of Health Research
- Keywords
- TelomereMitosisCell biologyBiologyDNAGenetics
- Has abstract in OpenAlex
- yes