Negative Regulation of Cell-proliferation of Adult Stem Cells in the Midgut and Hindgut by dMats in Drosophila melanogaster
Bibliographic record
Abstract
The existence of adult stem cells in the midgut and hindgut of Drosophila has been reported. The components of Hippo pathway such as dWarts and dYki were involved in the regulation of stem cell proliferation in the midgut. In this study, we reported the role of dMats in the control of stem cell proliferation in the midgut and hindgut of adult fruit fly. The eGFP signals driven by dmats indicated that dMats expressed in small diploid cells in the adult midgut and hindgut. By inducing MARCM cell clones, the dmats -/-cell clones in the midgut exhibited a bigger cell number than wild type cell clones and tissue outgrowth. Similarly, the dmats-/- mutation also caused more cell numbers in hindgut. Thus, dMats was critical to control stem cell proliferation in midgut as well as in hindgut. Our results implicated an important regulatory role for Hippo pathway in the regulation of adult stem cell proliferation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".