THE COENCAPSULATED HEPATOCYTES WITH BONE MARROW CELLS HEPATOCYTES VIABILITY AND FUNCTION EXTENDED BOTH IN VITRO AND IN VIVO
Bibliographic record
Abstract
The principle of artificial cell (Chang 1964) has been used for the bioencapsulation of islet, hepatocytes and other cells for immuno-isolation (Chang et al, CJPP 1966). We are now studying a new method to prolong hepatocytes viability and function. When bone marrow cells were co-encapsulated with hepatocytes, the viability of hepatocytes in culture was prolonged to 28 days, compared to 14 days when encapsulated hepatocytes were cultured alone. The ammonia removal capacity was maintained longer when hepatocytes were co-encapsulated with bone marrow cells. In vivo viability studies showed that co-encapsulated hepatocytes with bone marrow cells increased the hepatocytes' viability. In other in vivo study, the encapsulated cells were transplanted intra-peritoneally into hyperbilirubinemia Gunn rats. Hepatocytes co-encapsulated with bone marrow cells lowered the plasma bilirubin levels and maintained this lower levels significantly longer when compared to encapsulated hepatocytes during the period of 10 weeks after transplantation. The above results show that co-encapsulating hepatocytes and bone marrow cells improves the duration of hepatocytes viability and specific function in vitro and in vivo.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".