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Controversy concerning platelet dose

2007· article· en· W2078001819 on OpenAlexaff
Nancy M. Heddle

Bibliographic record

VenueISBT Science Series · 2007
Typearticle
Languageen
FieldMedicine
TopicBlood transfusion and management
Canadian institutionsMcMaster University
FundersNational Heart, Lung, and Blood Institute
KeywordsMedicineRandomized controlled trialPlateletClinical trialPlatelet transfusionExternal validityIntensive care medicineInternal validityInternal medicinePsychologyPathology

Abstract

fetched live from OpenAlex

The highest level of support for evidence based decisions is the randomized controlled trial (RCT); however, RCT results are only useful if the study has strong internal and external validity. There have been a number of clinical trials that have addressed the issue of the optimal platelet dose; however, none of these studies have provided definitive data on the optimal platelet dose due to a variety of methodological issues associated with the study designs. Currently two randomized controlled trials have been implemented to address the issue of optimal platelet dose. The results of these trials will not be available until 2007–2008. The BEST (Biomedical Excellence for Safer Transfusion) Collaborative has initiated a platelet dose study comparing the frequency of WHO bleeding Grade 2 with low and standard dose platelets. The Transfusion Medicine/ Haemostasis Clinical Trials Network (CTN) is also performing a platelet dose study comparing three treatment strategies (high, standard and low dose platelets). There were numerous methodological issues that had to be considered when designing these two studies. More recently some European investigators have questioned the need for prophylactic platelet transfusions and several studies are currently underway to investigate the efficacy of changing this practice.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.620
Threshold uncertainty score0.250

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.290
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2007
Admission routes1
Has abstractyes

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