Another Possible Underlying Mechanism for the Positive Association Between Celiac Disease and Systemic Lupus Erythematosus: The Role of Interleukin 21
Bibliographic record
Abstract
To the Editor: We read with great interest the recent contribution by Ludvigsson, et al 1. They reported the increased risk of systemic lupus erythematosus (SLE) in 29,000 patients with biopsy-verified celiac disease (CD) and suggested that the association of CD and SLE could be part of the spectrum of “shared autoimmunity.” We would like to add another pathomechanism of the association between the 2 diseases. SLE is a complex autoimmune disease characterized by dysregulated interactions between autoreactive … Address correspondence to Dr. J.I. Shin, Department of Pediatrics, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, CPO Box 8044, Seoul 120-752, Republic of Korea. E-mail: shinji{at}yuhs.ac
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.014 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.004 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.019 | 0.019 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".