Cinacalcet and Acute Heart Failure on Dialysis - A New Association
Bibliographic record
Abstract
Secondary hyperparathyroidism (SHPT) is common in end stage renal disease and is associated with abnormal bone and mineral metabolism, vascular calcification, bone fracture and increased cardiovascular risk. Cinacalcet is an increasingly widely-used calcimimetic agent for the control of SHPT in such patients and trial data has confirmed its use as an efficacious strategy in achieving target parathyroid hormone (PTH) targets. Here we describe a previously undocumented side-effect of cinacalcet treatment in a man on haemodialysis who developed a new and severe dilated cardiomyopathy in clear association with starting cinacalcet. This subsequently resolved fully after withdrawal of the drug. This case, we believe, is the first documented case of severe left ventricular systolic dysfunction temporally associated with cinacalcet use. J Med Cases. 2013;4(6):389-392 doi: https://doi.org/10.4021/jmc1029w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".