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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

2012· article· en· 418 citations· W2079350327 on OpenAlex· 10.1016/j.taap.2012.08.015

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.079
GPT teacher head0.380
Teacher spread
0.301 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Toxicology and Applied Pharmacology
Topic
Drug-Induced Hepatotoxicity and Protection
Field
Pharmacology, Toxicology and Pharmaceutics
Canadian institutions
Funders
National Institute of Environmental Health SciencesMcGill UniversityNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthNational Center for Research ResourcesNational Institute of General Medical Sciences
Keywords
AcetaminophenToxicityOxidative stressLiver injuryPharmacologyMitochondrionMechanism (biology)MedicineMetabolismChemistryBiologyInternal medicineBiochemistry
Has abstract in OpenAlex
no