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Estimating Survival and Association in a Semicompeting Risks Model

2007· article· en· W2079402423 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueBiometrics · 2007
Typearticle
Languageen
FieldMathematics
TopicStatistical Methods and Inference
Canadian institutionsUniversité Laval
FundersFonds Québécois de la Recherche sur la Nature et les Technologies
KeywordsEstimatorCopula (linguistics)MathematicsCensoring (clinical trials)StatisticsEconometricsApplied mathematics

Abstract

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In many follow-up studies, patients are subject to concurrent events. In this article, we consider semicompeting risks data as defined by Fine, Jiang, and Chappell (2001, Biometrika 88, 907-919) where one event is censored by the other but not vice versa. The proposed model involves marginal survival functions for the two events and a parametric family of copulas for their dependency. This article suggests a general method for estimating the dependence parameter when the dependency is modeled with an Archimedean copula. It uses the copula-graphic estimator of Zheng and Klein (1995, Biometrika 82, 127-138) for estimating the survival function of the nonterminal event, subject to dependent censoring. Asymptotic properties of these estimators are derived. Simulations show that the new methods work well with finite samples. The copula-graphic estimator is shown to be more accurate than the estimator proposed by Fine et al. (2001); its performances are similar to those of the self-consistent estimator of Jiang, Fine, Kosorok, and Chappell (2005, Scandinavian Journal of Statistics 33, 1-20). The analysis of a data set, emphasizing the estimation of characteristics of the observable region, is presented as an illustration.

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Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.026
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.693
Threshold uncertainty score0.982

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.026
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.239
GPT teacher head0.449
Teacher spread0.209 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it