The effects of 17β-estradiol injections on thyroid hormone deiodination pathways in liver and other tissues of female and male rainbow trout (<i>Oncorhynchus mykiss</i>) at different stages of sexual maturity
Bibliographic record
Abstract
The effects of two intraperitoneal injections of 17β-estradiol (E2) over 7 days were studied on thyroid hormone plasma levels and on activities of thyroxine (T4), 3,5,3'-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) outer-ring deiodination (ORD) and inner-ring deiodination (IRD) pathways in various tissues of female and male rainbow trout (Oncorhynchus mykiss (Walbaum, 1792)). E2 administered to adult females and males at different stages of sexual maturity increased liver mass, depressed plasma T3 levels with no change in plasma T4 levels, and severely decreased liver T4ORD activity. E2 also modestly depressed hepatic rT3ORD activity, but only at low substrate levels, and had no consistent effect on the hepatic IRD pathways. There were no E2-induced changes in brain, gill, or heart deiodination, but E2 increased kidney T3IRD activity. In contrast, an all-female stock of trout with rudimentary ovaries responded to E2 with an increase in liver mass but without change in plasma T4 and T3 levels or liver and brain deiodination activities. In conclusion, the decrease in plasma T3 levels in both male and female adult E2-injected trout may be due to both decreased hepatic T3 production and increased renal T3 degradation. However, thyroidal responses to E2 depend on physiological/developmental state and were absent in a highly immature all-female trout stock.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".