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Record W2079732393 · doi:10.1159/000249623

Characterization of Cellular Infiltrates in Skin Lesions of Atopic Eczema by Means of Monoclonal Antibodies

2009· article· en· W2079732393 on OpenAlex
Carla Rocha, Josianne de Maubeuge, M Sarfati, Micheline Song, G. Delespesse

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDermatologica · 2009
Typearticle
Languageen
FieldMedicine
TopicDermatology and Skin Diseases
Canadian institutionsUniversity of ManitobaResearch Manitoba
Fundersnot available
KeywordsDermisMonoclonal antibodyEpidermis (zoology)PathologyInfiltration (HVAC)Peripheral blood mononuclear cellAtopic dermatitisImmunofluorescenceMedicineCellular infiltrationAntibodyImmunologyChemistryInflammationAnatomyIn vitro

Abstract

fetched live from OpenAlex

Frozen skin biopsies from 3 acute and 3 chronic lesions of atopic dermatitis were examined by means of various ortho-monoclonal antibodies (OKT<sub>3,4 </sub>] = <S08_MathtechnicalPB>C</S08_MathtechnicalPB>4, OKT<sub>6</sub>, OKT<sub>8</sub>; OKI<sub>a</sub> and OKM<sub>1</sub>) in an indirect immunofluorescence technique. The results show that both T helper (T<sub>4</sub>) and T suppressor cytotoxic (T<sub>8</sub>) lymphocytes are present in the inflammatory infiltration which predominantly contained la mononuclear cells. Despite the absence of double staining procedure, the observations suggest that T<sub>4</sub> cells predominate over T<sub>8</sub> cells in the acute lesions whereas the reverse tendency is noted in the chronic lesions. T<sub>8</sub> cells are found mainly in the superficial dermis or even in the epidermis; by contrast, T<sub>4</sub> cells tend to be more deeply located in the dermis. The lesions are characterized by a dramatic increase in the number of Langerhans cells (OKT<sub>6</sub>, OKI<sub>a</sub>+) that are found not only in the epidermis but also in the dermis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.047
Threshold uncertainty score0.353

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.256
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it