Leukemic transformation of anaplastic large-cell lymphoma
Bibliographic record
Abstract
A 9-year-old boy was diagnosed with stage III ALK-positive anaplastic large cell lymphoma (ALCL) with no evidence of bone marrow and central nervous system disease.Seven months later he had a normocytic anemia (hemoglobin 79 g/L), severe thrombocytopenia (platelets 15 ϫ 10 9 /L), and leukocytosis (white blood cell count 50.8 ϫ 10 9 /L).The automated differential showed neutrophils 28.5 ϫ 10 9 /L, monocytes 13.2 ϫ 10 9 /L, and "other" cells 4.6 ϫ 10 9 /L.The peripheral blood smear (shown) contained large immature cells with basophilic cytoplasm and prominent cytoplasmic vacuolation.Karyorrhexis, pyknosis, and karyolysis were also seen in the large immature cells.Red blood cell morphology showed numerous echinocytes (also known as burr cells), which were likely a consequence of renal failure (creatinine 162M, urea 12.9mM).Flow cytometric immunophenoptyping on the peripheral blood showed that 55% of the cells expressed CD30, HLA-DR, and partial CD13.The cells expressing bright CD30 also expressed CD25.A diagnosis of leukemic transformation of ALCL was made.Microscopic review of the peripheral smear clarified the "automated differential" that was inaccurately reported.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".