Bibliographic record
Abstract
Human herpesviruses 6A and 6B (HHV-6A and HHV-6B) and human herpesvirus 7 (HHV-7) are viruses of the Roseolovirus genus in the betaherpesvirus subfamily, along with human cytomegalovirus. Roseoloviruses share many features of their genomic architecture and genetic content and the ability to replicate and establish latent infections in lymphocytes. Clinically, they cause febrile rash illnesses in young children and are associated with a variety of neurologic disorders. They are opportunistic pathogens in immunocompromised patients. HHV-6A has been identified during early-life febrile disease in Africa and in Hashimoto's thyroiditis; its clinical spectrum remains to be fully defined. HHV-6B is the main cause of roseola and related febrile rash illnesses in young children and is often active during posttransplant acute limbic encephalitis. HHV-7 causes a subset of roseola cases, and along with HHV-6B, has been identified in children with febrile status epilepticus. Human herpesvirus 8 (HHV-8), or Kaposi's sarcoma-associated herpesvirus, belongs to the gammaherpesvirus subfamily (as does Epstein-Barr virus). HHV-8 causes Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma, all of which are more likely to occur in HHV-8-seropositive individuals who are immunocompromised. Diagnosis of these viruses most often involves detection of their genomes by PCR, complemented by immunohistochemistry. Roseolovirus diagnosis is most often employed in the context of acute neurologic illnesses in young children and in organ and hematopoietic stem cell transplant recipients. HHV-8 diagnosis is employed in distinguishing Kaposi's sarcoma from its mimickers and for definitive diagnosis of its associated lymphoproliferative disorders.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.063 | 0.031 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".