Template Effects in the Formation of a Tetramethylene-Bridged Hemicarceplex
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Bibliographic record
Abstract
We report a study of the template effect in the formation of tetramethylene-bridged hemicarceplex 7 ·guest. Two tetrol cavitands were bridged with 1,4-dibromobutane in the presence of suitable template (guest) molecules in N -formylpiperidine as solvent. Selectivity was observed when competing templates were present during the reaction: the relative templating abilities (template ratios) of 30 different guest molecules range by 3600-fold, and manifest a significant preference for para-disubstituted benzenes. Twenty-one of the 30 hemicarceplexes used in this templation study are new. The trend in guest selectivity is markedly different from previous studies in which smaller cavities (e.g., carceplex 2 ·guest) are formed. In such studies, capsule 3 ·guest was a good transition state model, whereas this is not the case in the present work.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it