Coordinate regulation of stretch-activated channels and myogenic tone by polycystins 1 and 2
Bibliographic record
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is an adult-onset genetic disorder that typically affects the kidneys, liver and cardiovascular system. Clinically, it is characterized by the development of renal cysts that can lead to endstage renal disease. ADPKD is commonly linked to mutations in either polycystin-1 or polycystin-2 (aka PKD1 and PKD2, or TRPP1 and TRPP2), which are integral membrane proteins associated with cellular ion channel activity. Polycystin-1 is a large surface expressed protein (~4300 amino acids) containing 11 putative transmembrane-spanning segments and an extended extracellular N-terminus that appears to interact with components of the extracellular matrix. Structurally, it resembles a receptor or cell adhesion molecule. Polycystin-2 is a member of the transient receptor potential (TRP) channel family, and is capable of forming calciumpermeable cation channels. Due to its ER retention motif, polycystin-2 is largely localized to intracellular membrane compartments and it remains unclear whether channel activity is expressed at these locations. In complex with polycystin-1, however, polycystin-2 may be trafficked to the plasma membrane where it may form cation-selective channels. Interactions of this complex with other proteins, such as TRPC and TRPV channel subunits, and cytoskeletal elements, have also been reported. Functionally, both polycystin-1 and -2 are thought to contribute to intracellular calcium homeostasis. In the kidney and epi/endothelial layers, there is evidence that polycystin-1 and -2 are involved in mechanosensitivity to fluid
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".