Coordinate regulation of stretch-activated channels and myogenic tone by polycystins 1 and 2
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is an adult-onset genetic disorder that typically affects the kidneys, liver and cardiovascular system. Clinically, it is characterized by the development of renal cysts that can lead to endstage renal disease. ADPKD is commonly linked to mutations in either polycystin-1 or polycystin-2 (aka PKD1 and PKD2, or TRPP1 and TRPP2), which are integral membrane proteins associated with cellular ion channel activity. Polycystin-1 is a large surface expressed protein (~4300 amino acids) containing 11 putative transmembrane-spanning segments and an extended extracellular N-terminus that appears to interact with components of the extracellular matrix. Structurally, it resembles a receptor or cell adhesion molecule. Polycystin-2 is a member of the transient receptor potential (TRP) channel family, and is capable of forming calciumpermeable cation channels. Due to its ER retention motif, polycystin-2 is largely localized to intracellular membrane compartments and it remains unclear whether channel activity is expressed at these locations. In complex with polycystin-1, however, polycystin-2 may be trafficked to the plasma membrane where it may form cation-selective channels. Interactions of this complex with other proteins, such as TRPC and TRPV channel subunits, and cytoskeletal elements, have also been reported. Functionally, both polycystin-1 and -2 are thought to contribute to intracellular calcium homeostasis. In the kidney and epi/endothelial layers, there is evidence that polycystin-1 and -2 are involved in mechanosensitivity to fluid
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it