Sensing of bacteria immobilised under static conditions using long-range surface plasmon waveguides in Cytop
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Waveguides consisting of Au embedded in Cytop with micro-fluidic channels etched into the cladding are used for sensing via the propagation of long-range surface plasmons. Initially, a range of water/glycerol solutions with varying refractive indices were sequentially injected in a waveguide section in order to assess its bulk sensitivity and to find a solution supporting a strong high quality mode. Au waveguide surfaces were then functionalized with antibodies against Gram negative bacteria (Anti-Gneg) by first forming a self-assembled monolayer (SAM) of 16-mercaptohexadecanoic acid (16-MHA) and subsequent conjugation with antibodies through carbodiimide chemistry. E.Coli XL-1 Blue was used as an analyte in static incubations. Wavelength sweeps of 16-MHA covered waveguides were compared against waveguides covered with E-coli. The results indicate that very few bacteria cells are required to obtain a measurable change in output signal.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it