Myocardial fatty acid utilization as a determinant of cardiac efficiency and function
Bibliographic record
Abstract
Cardiac efficiency describes the relationship between cardiac work, an index of function, and oxygen consumption, an index of energy substrate metabolism. As the heart obtains upwards of 95% of its ATP requirements from oxidative metabolism the choice of energy substrate strongly impacts cardiac efficiency. The increased utilization of fatty acids relative to glucose as an energy substrate decreases cardiac efficiency. This effect is attributable to differing phosphorous/oxygen ratios of fatty acid and glucose metabolism, increased mitochondrial uncoupling induced by increased rates of fatty acid oxidation, futile cycles engaged by fatty acids and effects of fatty acid use on cardiac ionic homeostasis. Increasing myocardial glucose utilization at the expense of fatty acid utilization can improve cardiac efficiency in various pathophysiologies characterized by an increased reliance on fatty acids as an energy substrate. In this review we present current information regarding the mechanisms contributing to the effects of fatty acids on cardiac efficiency.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".