Immunology of the host–parasite relationship in fasciolosis (<i>Fasciola hepatica</i>and<i>Fasciola gigantica</i>)
Bibliographic record
Abstract
The protective resolution of liver fluke (Fasciola hepatica and Fasciola gigantica) infection is a dynamic interplay between the host's effector responses and the parasite's defence and immunomodulatory systems. The evidence suggests that the juvenile or immature parasite is the target of protective host immune responses but the effector mechanisms employed vary between hosts. Moreover, F. hepatica and F. gigantica differ in their susceptibility to these killing mechanisms. In the rat, in vitro killing of juvenile F. hepatica involves an antibody-dependent cell cytotoxicity mediated by nitric oxide produced by activated monocytes and (or) macrophages. However, monocytes and (or) macrophages from Indonesian sheep do not produce nitric oxide yet can effectively kill juvenile F. gigantica in vitro and in vivo by a mechanism that is ineffective against F. hepatica. These data show that disease progression or resolution in fasciolosis is determined both by biochemical differences between Fasciola species and by host-dependent factors. Understanding the genetic basis for these differences is a key question for the future. Fasciola hepatica and F. gigantica actively modulate the host immune response, downregulating type 1 responses during infection. It is important to determine whether such modulation of the immune response by Fasciola spp. directly leads to enhanced parasite survival in the various hosts.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".