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Record W2084281933 · doi:10.1007/s12263-010-0192-8

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

2010· article· en· W2084281933 on OpenAlexafffund
Ben van Ommen, Ahmed El‐Sohemy, John E. Hesketh, Jim Kaput, Michael Fenech, Chris T. Evelo, Harry J McArdle, Jildau Bouwman, Georg Lietz, John C. Mathers, Henk van Kranen, Ruan Elliott, Suzan Wopereis, Lynnette R. Ferguson, Catherine Méplan, Giuditta Perozzi, Lindsay H. Allen, Damaríz Rivero

Bibliographic record

VenueGenes & Nutrition · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNutrition, Genetics, and Disease
Canadian institutionsUniversity of Toronto
FundersCanadian Institutes of Health ResearchU.S. Food and Drug AdministrationPublic Health AgencyPublic Health Agency of CanadaAdvanced Foods and Materials Network
KeywordsNutrigenomicsMicronutrientToolboxContext (archaeology)Data scienceGenomicsBiotechnologyBioinformaticsComputer scienceComputational biologyKnowledge managementBiologyMedicineGenomeGeneticsPathology

Abstract

fetched live from OpenAlex

Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients in their complete biological context. Existing research collects fragments of information, which are not stored systematically and are thus not optimally disseminated. The Micronutrient Genomics Project (MGP) was established as a community-driven project to facilitate the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient-genome interactions. Specifically, the MGP creates a public portal and open-source bioinformatics toolbox for all "omics" information and evaluation of micronutrient and health studies. The core of the project focuses on access to, and visualization of, genetic/genomic, transcriptomic, proteomic and metabolomic information related to micronutrients. For each micronutrient, an expert group is or will be established combining the various relevant areas (including genetics, nutrition, biochemistry, and epidemiology). Each expert group will (1) collect all available knowledge, (2) collaborate with bioinformatics teams towards constructing the pathways and biological networks, and (3) publish their findings on a regular basis. The project is coordinated in a transparent manner, regular meetings are organized and dissemination is arranged through tools, a toolbox web portal, a communications website and dedicated publications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.043
metaresearch head score (Gemma)0.069
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.043
Threshold uncertainty score0.225

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0430.069
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0130.017
Science and technology studies0.0040.002
Scholarly communication0.0110.007
Open science0.0080.017
Research integrity0.0050.005
Insufficient payload (model declined to judge)0.0150.010

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.045
GPT teacher head0.348
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations50
Published2010
Admission routes2
Has abstractyes

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