Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
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Abstract
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.
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The record
- Venue
- Science
- Topic
- interferon and immune responses
- Field
- Immunology and Microbiology
- Canadian institutions
- Jewish General Hospital
- Funders
- —
- Keywords
- InterferonInterferon regulatory factorsIκB kinaseKinaseTranscription factorCell biologyTANK-binding kinase 1Signal transductionBiologyCancer researchVirologyMAP kinase kinase kinaseNF-κBProtein kinase AGeneticsGene
- Has abstract in OpenAlex
- yes