STUDIES ON THE REACTIONS OF 2,3-DIKETOPYRIDO[4,3,2-de] QUINOLINES WITH AMINO ACIDS AND AMINO ESTERS
Bibliographic record
Abstract
A reaction of 23-diketopyrido[4,3,2-<te]quinolines with α, β, γ, δ, ε and ω amino acids and amino esters in the presence of triethylamine is described.The reaction is simple in execution and work-up, occurring under ambient conditions.In recent years, many new heterocyclic alkaloids have been isolated from marine sources, characterized and synthesized, and the biological activities have also been reported for some of these compounds 1 -5 .The cystodytins are obtained from the Okinawan tunicate, cystodytes dellechiajei(De\\a Valle) 6 and exhibit significant antineoplastic properties.The mixture of cystodytin A and cystodytin Β exhibited high cytotoxicity with JC50: 6.7 χ ΙΟ 7 Μ toward L1210 murine CH=C(CH3) 2 , Cystoditin A pyrido[43,2-de]quinoline skeleton R = C(CH 3 )=CH(CH3).Cystoditin Β Dercitin leukemia.Studies of bioactivities for the structurally related dercitin show that the compound has in vitro antitumor against P388 (IC50 equal to 50 ng/mL) and human tumor cell lines (HCT-8, A-549, T47D, 1.0 ^g/mL) and in vivo activity against P388 (T/C 170%, 5mg/kg).Dercitin also exhibits immunosuppressant activity(% murine MLR at 10ng/mL) 7 .These alkaloids contain a
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".