Diagnosis of Von Willebrand Disease in Children
Bibliographic record
Abstract
Von Willebrand disease (VWD) is an inherited bleeding disorder that is caused by deficiency or dysfunction of Von Willebrand factor, a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and also binds and stabilizes blood clotting factor VIII in the circulation. VWD prevalence has been estimated in several countries on the basis of the number of symptomatic patients seen at haemostasis centers, and the values range from roughly 23 to 110 per million population. VWD is characterized by three key features: a personal history of excessive mucocutaneous bleeding, abnormal VWF laboratory studies, and evidence of a family history of the condition. Although bruising and epistaxis are common among children who have VWD, these symptoms also are reported in normal children. The accurate assessment of hemorrhagic symptoms is a key component in diagnosing VWD but this can present a significant challenge, particularly in the pediatric population. The challenges involved in making the diagnosis of Von Willebrand disease - focusing on personal bleeding history and the utility of bleeding questionnaires, along with family bleeding history and laboratory diagnosis in the pediatric population - will be reviewed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".