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Record W2086116132 · doi:10.1038/mp.2008.135

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

2008· review· en· W2086116132 on OpenAlexafffund
Mandy Ng, Douglas F. Levinson, Stephen V. Faraone, Brian K. Suarez, Lynn E. DeLisi, Tadao Arinami, Brien P. Riley, Tiina Paunio, Ann E. Pulver, Irmansyah, Peter Holmans, Michael Escamilla, Dieter B. Wildenauer, Nigel Williams, Claudine Laurent, Bryan Mowry, Linda M. Brzustowicz, Michel Maziade, Pamela Sklar, D. Garver, Gonçalo R. Abecasis, Bernard Lerer, M. Daniele Fallin, Hugh Gurling, Pablo V. Gejman, Eva Lindholm, Hans W. Moises, William Byerley, Ellen M. Wijsman, Paola Forabosco, Ming T. Tsuang, Yozo Okazaki, Kenneth S. Kendler, Brandon Wormley, Ayman H. Fanous, Dermot Walsh, F. Anthony O’Neill, Laura‐Maria Peltonen, Gerald Nestadt, Virginia K. Lasseter, Kung‐Yee Liang, G. Papadimitriou, Dimitris Dikeos, Sibylle G. Schwab, Michael J. Owen, Michael O‘Donovan, Nadine Norton, Elizabeth Hare, Henriette Raventós, Humberto Nicolini, Margot Albus, W. Maier, Vishwajit L. Nimgaonkar, Lars Terenius, Jacques Mallet, Melanie Jay, Stephanie Godard, Deborah A. Nertney, Madeline Alexander, R R Crowe, Jeremy M. Silverman, Anne S. Bassett, M-A Roy, Chantal Mérette, Carlos N. Pato, Michele T. Pato, Johannes L. Roos, Yoav Kohn, Daniela Amann‐Zalcenstein, G. Kalsi, Andrew McQuillin, David Curtis, Jon Brynjolfson, Thordur Sigmundsson, Hannes Pétursson, Alan R. Sanders, Jubao Duan, Elena Jazin, Marina Myles‐Worsley, Maria Karayiorgou, Cathryn M. Lewis

Bibliographic record

VenueMolecular Psychiatry · 2008
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental HealthUniversité Laval
FundersJapan Science and Technology AgencyNational Health and Medical Research CouncilMedical Research CouncilCanadian Institutes of Health ResearchUniversity of Texas Health Science Center at San AntonioNational Taiwan UniversityJohns Hopkins UniversityNational Taiwan University HospitalHáskóli ÍslandsCore Research for Evolutional Science and TechnologyUniversidad de Costa RicaNational Health Research InstitutesDeutsche ForschungsgemeinschaftEuropean Science FoundationWellcome TrustNational Alliance for Research on Schizophrenia and DepressionNational Institute of Mental HealthNational Heart, Lung, and Blood InstitutePfizerU.S. Department of Veterans Affairs
KeywordsGenome ScanLinkage (software)GeneticsGenomeAutosomePedigree chartGenetic linkageLocus (genetics)BiologyChromosomeGenome-wide association studyComputational biologyAlleleMicrosatelliteSingle-nucleotide polymorphismGeneGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.008
Threshold uncertainty score0.045

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0080.012
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.008
Bibliometrics0.0030.006
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.361
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations281
Published2008
Admission routes2
Has abstractno

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