The Peptidase Zymogen Proregions: Natures Way of Preventing Undesired Activation and Proteolysis
Bibliographic record
Abstract
Since the initial description of a peptidase activity, namely pepsin, in the middle of the 19(th) century, our understanding of the molecular basis of peptidase function and activation has greatly improved. Further, by sequencing entire genomes, we have reached a stage whereby it is now possible to appreciate the tremendous diversity and unique specificities of peptidases. Because of their importance in most if not all vital processes of the cell including ultimately its death, their activities must be carefully localized and kept under tight control. In addition to endogenous inhibitors, control of enzymatic activity can be achieved through their synthesis and transport as inactive zymogens. This review article will focus on the characteristics as well as the role of the proregion contained within the peptidase zymogen structure. It will survey novel zymogen structures determined in the past 5 years as well as those of selected emerging peptidase families for which there exists as yet no or little structural data. These include members belonging to the caspase, ADAMS, TTSP, MMP, Aspartyl peptidases and convertase families.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".