Stability and oscillation of genetic regulatory networks with time delays
Bibliographic record
Abstract
From biochemical reaction principles, a genetic regulatory network can be described by a group of nonlinear differential equations with time delays. Previous studies have investigated delay-independent stability of genetic regulatory networks with time delays. However, if it is delay-independently stable, a genetic regulatory network loses other interesting properties such as oscillation. In this paper, we provide a computational method for computing the maximal delay interval over which the genetic regulatory network maintains stability, and beyond which the network will not be stable. Furthermore we prove that when its delay is exactly the maximal delay the network is oscillated. In addition, the formula for calculating the oscillation period is presented. The autoregulatory genetic network in zebrafish is used as an example to illustrate the presented method. The oscillation period calculated from our method is very close to that observed from the real-life of a zebrafish, which indicates the effectiveness of our method.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".