Effect of Metiamide, a Histamine Antagonist of H <sub>2</sub> -Receptors, on Acid Secretion of Isolated Canine Stomach Perfused with Homologous Blood
Bibliographic record
Abstract
The totally isolated canine stomach, perfused with homologous blood, was used to study the inhibitory action of metiamide, a histamine antagonist of the H<sub>2</sub>-blocking variety. Secretagogues, histamine or bethanechol chloride were infused separately or combined into the gastric artery for 6–7 h. When a basic secretion level was achieved after 2–3 h, metiamide was infused for 2 h, then infusion of secretagogue(s) continued for the remaining 2–3 h. Under all conditions of stimulation used in this study, metiamide significantly inhibited the concentration and output of HCl. In all stomachs studied there was a complete absence of titrable H+ at a certain stage of metiamide infusion or following such an infusion. These results indicate that the action of metiamide is not selectively limited to the antagonism of H<sub>2</sub>-receptors. Metiamide acts against both H<sub>2</sub>-receptors and muscarinic receptors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".