Effect of Metiamide, a Histamine Antagonist of H <sub>2</sub> -Receptors, on Acid Secretion of Isolated Canine Stomach Perfused with Homologous Blood
Bibliographic record
Abstract
The totally isolated canine stomach, perfused with homologous blood, was used to study the inhibitory action of metiamide, a histamine antagonist of the H2-blocking variety. Secretagogues, histamine or bethanechol chloride were infused separately or combined into the gastric artery for 6–7 h. When a basic secretion level was achieved after 2–3 h, metiamide was infused for 2 h, then infusion of secretagogue(s) continued for the remaining 2–3 h. Under all conditions of stimulation used in this study, metiamide significantly inhibited the concentration and output of HCl. In all stomachs studied there was a complete absence of titrable H+ at a certain stage of metiamide infusion or following such an infusion. These results indicate that the action of metiamide is not selectively limited to the antagonism of H2-receptors. Metiamide acts against both H2-receptors and muscarinic receptors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".