Depression of Respiration Induced by Metabolic Acidosis in Newborn Lambs
Bibliographic record
Abstract
The present study evaluates the strength of the drive to breathe and the respiratory response of newborns to metabolic acidosis. The study consisted in a HCl mild and severe acidosis induced in 30 unanesthetized newborn lambs aged from 2 to 90 days. During mild acidosis (pHa = 7.20), all lambs experienced an increase in the minute ventilation (VE) associated with an increase in the neuromuscular drive of breathing which was measured by the occlusion pressure (PO.1). However, with severe acidosis (pHA = 7.10) both VE and PO.1 decreased towards the preacidotic level in the 2- and 10-day-old lambs but continued to increase in older lambs. It is concluded that newborn lambs have an immature drive of breathing and a blunted respiratory output to metabolic acidosis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".