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Record W2088268136 · doi:10.1038/gene.2013.1

Pathway-based analysis of primary biliary cirrhosis genome-wide association studies

2013· article· en· W2088268136 on OpenAlexafffund
Siddhartha Kar, Michael F. Seldin, W. Chen, E. Lu, Gideon M. Hirschfield, Pietro Invernizzi, Jenny Heathcote, Daniele Cusi, Piero Luigi Almasio, Domenico Alvaro, Pietro Andreoné, Angelo Andriulli, Cristina Barlassina, A. Benedetti, Francesca Bernuzzi, Ilaria Bianchi, Maria Consiglia Bragazzi, Maurizia Rossana Brunetto, Savino Bruno, Lisa Caliari, Giovanni Casella, B. Coco, Agostino Colli, Massimo Colombo, Sílvia Colombo, Carmela Cursaro, Lory Saveria Crocè, Andrea Crosignani, Francesco Donato, G. Elia, Luca Fabris, Annarosa Floreani, Andrea Galli, Ignazio Grattagliano, Roberta Lazzari, Ana Lleò, Fabio Salvatore Macaluso, Fabio Marra, Marco Marzioni, Elisabetta Mascia, Alberto Mattalia, R. Montanari, Lorenzo Morini, Filomena Morisco, Luigi Muratori, Paolo Muratori, Grazia Anna Niro, Mauro Podda, Piero Portincasa, Daniele Prati, Chiara Raggi, F. Rosina, Sonia Rossi, Ilaria Sogno, Giancarlo Spinzi, Mario Strazzabosco, Sonia Tarallo, Mirko Tarocchi, Claudio Tiribelli, Pierluigi Toniutto, Maria Cristina Vinci, Massimo Zuin, M. Eric Gershwin, Kathy Siminovitch, Christopher I. Amos

Bibliographic record

VenueGenes and Immunity · 2013
Typearticle
Languageen
FieldMedicine
TopicLiver Diseases and Immunity
Canadian institutionsToronto Western HospitalUniversity of Toronto
FundersNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesCanadian Institutes of Health Research
KeywordsGenome-wide association studyBiologyPrimary biliary cirrhosisKEGGGenetic associationGeneticsHedgehog signaling pathwayGeneComputational biologyBioinformaticsImmunologySingle-nucleotide polymorphismTranscriptomeGene expressionGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.003
Bibliometrics0.0030.004
Science and technology studies0.0010.000
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.251
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations54
Published2013
Admission routes2
Has abstractno

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