Apoptosis in the mature and developing olfactory neuroepithelium
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Neuronal apoptosis is important in the developmental sculpting of a normal nervous system and also in the loss of neurons caused by neurodegenerative disease, ischemia or trauma. In a developing embryo, exquisite mechanisms of regulation exist to balance factors that control neuronal birth and death within a given neuronal group, so that sufficient neurons develop and survive to elicit normal function. Postnatally, the only part of the mammalian nervous system where many of these regulatory balance mechanisms are retained is the olfactory epithelium (OE). During the last 30 years, researchers investigating olfactory receptor neuron cellular and developmental biology have focussed on the regeneration of the neuronal population within the olfactory neuroepithelium, following the induced death of the mature neuronal population. This body of work has thus far overshadowed the equally important and intrinsically linked phenomenon of the death of mature olfactory receptor neurons, which is required to initiate regeneration. The purpose of this review is to reveal what has been established about the different forms of cell death that can occur in neurons of the olfactory epithelium, and highlight the identified pro- and anti-apoptotic pathways that control the normal and induced turnover of olfactory receptor neurons.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it