HFE inhibits apical iron uptake by intestinal epithelial (Caco‐2) cells
Bibliographic record
Abstract
ABSTRACT Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism characterized by increased intestinal iron absorption, which leads to progressive iron overload. The protein product of C282Y, the main mutation observed in HH, has lost the capacity to associate with β 2 ‐microglobulin, preventing its targeting to the plasma membrane. The physiological mechanisms by which HFE, the normal product of the HH gene, regulates intestinal iron absorption are unknown. Under the hypothesis that HFE regulates intestinal iron absorption, we characterized the effect of HFE overexpression on apical iron uptake in intestinal epithelial Caco‐2 cells. We found that the primary effect of HFE overexpression was a marked reduction of apical iron uptake, despite a working iron responsive element/iron regulatory protein system and an eightfold increase in the mass of the iron transporter DMT1. The inhibitory effect of HFE on apical iron uptake reported here provides an explanation for the increased absorption of iron observed in HH, where the normal function of HFE is lost.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".