T01-O-16 Restoration of female genital vasocongestive arousal responses in young and aged rats
Bibliographic record
Abstract
To examine whether the actions of nitric oxide (NO) were critical to the apomorphine-generated genital vasocongestive arousal (GVA) responses in both intact and ovariectomized (OVX) young adult female rats. We also investigated whether the diminished GVA responses in aged rats could be restored using an antihypertensive treatment. In female Wistar rats (n=8), apomorphine- induced GVA responses were assessed following various treatments. Young adult females were ovariectomized or treated with the NO synthase (NOS) inhibitor Nnitro-L-arginine methyl ester (30mg/kg, i.v.) followed by an NO-mimetic, sodium nitroprusside (10mg/kg/min, i.v.). Aged females (18 months-old; n=8) were treated for 2 weeks with the angiotensin converting enzyme inhibitor (ACEI) enalapril (30mg/kg per day, p.o.) + low sodium (0.04%). Age-associated reduction in sexual responses in normotensive rats was greatly enhanced by brief, aggressive antihypertensive treatment. The enhanced vasocongestive responses persisted for 5 weeks off-treatment. Both OVX and NOS inhibition significantly decreased sexual responses in the young female rats. Systemic administration of an NO-mimetic recovered vasocongestive responses in the NOS blocked rats, but not in OVX animals. Brief aggressive ACEI treatment markedly improved sexual responses in aged female rats, and systemic delivery of a NO-mimetic recovered sexual responses in globally NOS blocked animals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".