Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin
Bibliographic record
Abstract
Letters6 November 2007Bridging Low-Molecular-Weight Heparin for Temporary Interruption of WarfarinMartin J. O'Donnell, MB, Clive Kearon, MB, PhD, and Alexander G. Turpie, MBMartin J. O'Donnell, MBFrom McMaster University, Hamilton, Ontario L8V 1C3, Canada.Search for more papers by this author, Clive Kearon, MB, PhDFrom McMaster University, Hamilton, Ontario L8V 1C3, Canada.Search for more papers by this author, and Alexander G. Turpie, MBFrom McMaster University, Hamilton, Ontario L8V 1C3, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate the opportunity to respond to issues raised by Dr. Shojania. We agree that the therapeutic anti-Xa heparin level range for LMWH has not been rigorously evaluated; however, the high residual anti-Xa heparin activity observed in our study is a cause for concern because it may increase bleeding during surgery. We believe that when physicians stop warfarin therapy before surgery, they do not intend to substitute another anticoagulant during the surgical procedure.The difference in mean anti-Xa heparin levels between our study and the study by Ferreira and colleagues (1) is not surprising because their patient population ...Reference1. Ferreira I, Dos L, Tornos P, Nicolau I, Permanyer-Miralda G, Soler-Soler J. Experience with enoxaparin in patients with mechanical heart valves who must withhold acenocumarol. Heart. 2003;89:527-30. [PMID: 12695457] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From McMaster University, Hamilton, Ontario L8V 1C3, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Preoperative Anticoagulant Activity after Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin Martin J. O'Donnell , Clive Kearon , Judy Johnson , Marlene Robinson , Michelle Zondag , Irene Turpie , and Alexander G. Turpie Bridging Low-Molecular-Weight Heparin for Temporary Interruption of Warfarin A. M. Shojania Metrics 6 November 2007Volume 147, Issue 9Page: 671KeywordsAnticoagulant therapyAnticoagulantsClinical trialsCohort studiesConflicts of interestHemorrhageHeparinSafetySurgery ePublished: 6 November 2007 Issue Published: 6 November 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.035 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".