Interleukin 10 (<i>IL‐10</i>) gene variants and susceptibility for paediatric onset Crohn’s disease
Bibliographic record
Abstract
Summary Background A recent genome‐wide association study in adult patients with ulcerative colitis (UC) has implicated the interleukin 10 (IL‐10) gene as an important candidate gene. Moreover, a UC‐associated single nucleotide polymorphism (SNP) rs3024405 was also significantly associated with adult Crohn’s disease (CD). Aims To examine whether IL‐10‐CD associations extended to paediatric‐onset CD. Methods We implemented the case‐control design at three paediatric gastroenterology clinics in Canada. CD patients (≤20 years) were recruited along with healthy controls. DNA samples were genotyped for tag‐single nucleotide polymorphisms (tag‐SNPs) in the IL‐10 gene. Allelic, genotype and haplotype associations with CD were studied. Results A total of 270 patients and 336 controls were studied. The mean age (±s.d.) at diagnosis was 12.1 (±3.5). There were a slightly higher proportion of male patients (56.3%). Of the five IL‐10 tag‐SNPs, rs2222202 (C/T) (P = 0.03) and rs1800871 (C/T) (P = 0.05) showed significant allelic associations with CD. Specific IL‐10 SNPs were associated with CD disease location and/or disease behaviour. Conclusions Our gene‐wide analysis replicates recent findings of associations between IL‐10 and adult CD, and suggests that these associations extend to paediatric‐onset CD as well.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".