Rebamipide-Promoted Restoration of Gastric Mucosal Sonic Hedgehog Expression after Early Helicobacter Pylori Eradication
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Bibliographic record
Abstract
trolled trial, rebamipide significantly promoted gastric ulcer healing following eradication. Here, the effect of rebamipide on the restoration of Shh expression after H. pylori eradication was assessed. The data of gerbils with chow diet used in this study were previously examined and partially reported, in terms of eradication and Shh regeneration [3] . The experimental design is shown in figure 1 . In experiment I, 32 male Mongolian gerbils (MGS/Sea) were divided into 2 groups. Gerbils assigned to the H. pyloriinfected group (I group, n = 16) and the H. pylori infected group administered eradication therapy (I+E group, n = 16) were administered H. pylori suspensions at the age of 5 weeks. For H. pylori eradication, lansoprazole (10 mg/kg), amoxicillin (3 mg/kg) and clarithromycin (30 mg/kg; in 0.5% wt/wt carboxymethyl cellulose sodium salt) were administered intragastrically twice daily on 2 successive days 12 weeks after bacterial inoculation [3] . After eradication, the animals in both the I group and the I+E group were further subdivided into the chow diet and rebamipide-containing diet groups (0.25%) [6] . Ten weeks after eradication, the gerbils were examined under ether anesthesia. In experiment II, eradication was carried out 24 weeks after inoculation, and in experiment III, 48 weeks after inoculation. Myeloperoxidase (MPO) Dear Sir, Sonic hedgehog (Shh) is a soluble signal that is secreted in concentration gradients through a tissue and regulates epithelial cell differentiation. Disturbances of epithelial cell differentiation induced by Helicobacter pylori -associated gastritis in Mongolian gerbils are correlated closely with changes in Shh expression [1] . We previously reported that suppressed Shh expression in the gastric mucosa by H. pylori infection was significantly restored following eradication of the bacterium, in both humans [2] and Mongolian gerbils [3] . H. pyloriassociated deregulation of Shh expression was reversible after H. pylori eradication. The restoration of Shh expression was confirmed by immunohistochemistry, mRNA expression and in situ hybridization in Mongolian gerbils [3] . Earlier eradication promoted better restoration of the Shh expression in the gastric mucosa of the Mongolian gerbil [3] . Rebamipide, 2-(4-chlorobenzoylamino)-3-[2-(1H)-quinolinon-4-yl]propionic acid, has been reported to exert a preventive effect on drug-induced gastric ulcer formation by inhibiting neutrophil activation [4] . The drug has oxygen radical scavenging effects and stimulates prostaglandin generation in the gastric mucosa. Terano et al. [5] recently reported that in a randomized, double-blind, placebo-conPublished online: May 7, 2009
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it