Leishmaniasis-Associated Hemophagocytic Syndrome Revisited: Not an Uncommon Clinical Presentation of Leishmaniasis
Bibliographic record
Abstract
Visceral leishmaniasis (VL) is an uncommon but important cause of reactive hemophagocytic syndrome (HS) that should be seriously considered in patients coming from endemic areas. We describe two cases of VL-associated HS; a young woman with fever, cytopenias and hyperferritinemia and an immunocompromised patient with fever, splenomegaly, hyperferritinemia and pancytopenia. The diagnosis of leishmaniasis was established with polymerase chain reaction for leishmania and bone marrow examination, whereas leihmaniasis specific treatment with liposomal amphotericin led to full clinical recovery and complete remission of HS. From the clinical point of view, it should be emphasized that the high clinical suspicion along with the use of modern, high yield diagnostic tools, may lead to early diagnosis of VL-associated HS, minimizing unnecessary hospitalization and potentially harmful investigations and treatments. doi:10.4021/jmc715w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".