Spontaneous Complete Necrosis of Hepatocellular Carcinoma: Possible Immune System Hypothesis
Bibliographic record
Abstract
Spontaneous regression of hepatocellular carcinoma (HCC) is an extraordinarily unusual phenomenon. The mechanisms underlying this intriguing phenomenon remain unknown. We report a 72-year-old man with a liver mass. MR pictures demonstrate arterial hypervascularity with venous washout. We performed a fine-needle aspiration cytology of this nodule and it allowed us to find an HCC well differentiated. Postoperative histopathologic findings demonstrated a spontaneous complete necrosis of HCC. The necrotic tissue was filled with large debris from a neoplastic tissue, regardless of no viable tumor cells were seen among them. The patient is alive and well for 2 years after surgery. The underlying mechanism of this phenomenon is not clear. The histologic findings of our patient are including the tumor necrosis, the severe inflammatory infiltration with lymphocytes and the thick fibrous capsule. We speculate that some immune mechanism may be involved in regression of HCC. J Curr Surg. 2014;4(1):26-28 doi: http://dx.doi.org/10.14740/jcs 204 w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".