Correlation between the Outputs of Pepsin and HCl by Isolated, ex vivo Perfused, Canine Stomach Stimulated with Humoral and Cholinergic Drugs
Bibliographic record
Abstract
The totally isolated canine stomach, perfused with homologous blood, was chloride used for the study of gastric pepsin and HCl. Secretion was stimulated for several hours by intra-arterial infusion of histamine, pentagastrin and bethanechol chloride, given separately or combined. The ratio of outputs of pepsin and HCl (P-O/HCl-O) were calculated. The relationship between paired values of pepsin (mg/30 min) and H+ (mEq/30 min) was analyzed by computer and the linear correlation was calculated between these two values. Bethanechol chloride was found to be a very strong stimulant of pepsin and high (P-O/HCl-O) ratios were found in the presence of cholinergic stimulation applied separately or in combination with the humoral secretagogues used. Bethanechol chloride potentiated the effect of histamine and pentagastrin on pepsin secretion. No such potentiation was observed when histamine was combined with pentagastrin. The relationship between pepsin and acid expressed by (P-O/HCl-O) ratio, was dependent upon the secretagogue used. Linear regression lines satisfactorily characterized the relationship between pepsin and H+ outputs under all conditions of stimulation applied in this experiment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".