Mutagenic and Carcinogenic Hazards of Settled House Dust II: Salmonella Mutagenicity
Bibliographic record
Abstract
Settled house dust (SHD) is a complex mixture that contains numerous chemical contaminants. Very little is known about the hazards of SHD as compared to other complex matrices such as air and soil. In this study, the mutagenic hazards associated with the extracts of sieved dust from 52 homes were examined using the Salmonella Mutagenicity Test. All of the SHD samples displayed mutagenic activity and the mean mutagenic potencies ranged from 2300to 23 600 revertants per gram. Testing with various Salmonella strains revealed a predominance of frameshift mutagens in the dust samples. Analyses showed that polycyclic aromatic hydrocarbons (PAHs) were likely responsible for a quarter of the mutagenic activity of the SHD samples. In an effort to identify factors that influenced dust mutagenicity, the relationships between SHD mutagenicity and household activities were investigated. Mutagenicity was positively correlated with parameters such as the time since last vacuuming (r2 = 0.11, p < 0.05) and the number of people living in the home (r2 = 0.11-0.43, p < 0.05). However, the causative factors responsible for these relationships remain unclear.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".