Efficacy of medical grade honey against multidrug-resistant organisms of operational significance
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
In vitro efficacy of medical grade honey against multidrug-resistant organisms; 'validation' here is laboratory antimicrobial testing, and the object is wound treatment.
The study tests medical honey against resistant organisms, not research itself.
Clinical microbiology efficacy of medical-grade honey against pathogens; therapeutic domain.
Abstract
BACKGROUND: MEDIHONEY (Derma Sciences, Inc., Toronto, Ontario M1S 3S4, Canada) was cleared by the Food and Drug Administration for use on tramatic wounds, diabetic ulcers, and second-degree burns against normal skin flora but not necessarily against multidrug-resistant organisms (MDROs) infecting these wounds or its associated recovery and healing rate. METHODS: Here, we report on the efficacy of this medical grade honey treatment against two MDROs (Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus [MRSA]). In this initial phase (Part I), an in-laboratory validation and characterization of the efficacy against antibiotic-resistant bacteria were performed in vitro. RESULTS: The antimicrobial resistance of both MDROs was confirmed in vitro using standard microbiology techniques and species' DNA signatures. The minimum inhibitory concentration of the MEDIHONEY was determined to be 3.5% for MRSA and 8.5% for A. baumannii. The minimum bactericidal concentrations determined against MRSA and multidrug-resistant A. baumannii were shown to be 9.5% and 10.5%, respectively. CONCLUSION: Our in vitro findings support the efficacy of MEDIHONEY against MRSA and A. baumannii as requested by first responders. We also conducted screening assays using other "supermarket brands" of honey. All cultures from the latter showed bacterial and fungal growths. The use of supermarket brand honey for wound treatment is discouraged.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- The Journal of Trauma: Injury, Infection, and Critical Care
- Topic
- Bee Products Chemical Analysis
- Field
- Agricultural and Biological Sciences
- Canadian institutions
- —
- Funders
- Air Force Surgeon GeneralCongressionally Directed Medical Research ProgramsU.S. Air Force
- Keywords
- Acinetobacter baumanniiMicrobiologyStaphylococcus aureusMultiple drug resistanceAntimicrobialAntibioticsClearanceMedicineMinimum inhibitory concentrationMethicillin-resistant Staphylococcus aureusAcinetobacterDrug resistanceBiologyBacteriaPseudomonas aeruginosa
- Has abstract in OpenAlex
- yes