Serologic profile of a cohort of pigs and antibody response to an autogenous vaccine for <i>Actinobacillus suis</i>
Bibliographic record
Abstract
Actinobacillus suis is a commensal opportunistic pathogen in swine.However, in recent years, an increasing prevalence of clinical signs associated with A. suis has been observed in high health status herds in North America.The objectives of the study were to assess the kinetics of antibodies to A. suis in pigs from a herd showing clinical signs of A. suis infection and, to evaluate the antibody response in gilts following vaccination with an autogenous vaccine.An enzyme-linked immunosorbent assay (ELISA) using a saline extract of boiled-formalinized whole cells of a field strain as the coating antigen was standardized.This ELISA was used as a tool for monitoring, in a comparative way, the variations in A. suis antibody levels.The herd selected for the serologic profile was negative for Actinobacillus pleuropneumoniae infection and showed clinical signs of A. suis infection in 16 to 19-week-old pigs.A cohort of 20 pigs was blood sampled at 5, 8, 12, and 16 weeks of age.The lowest level of serum antibodies was observed between weeks 8 and 12, this probably corresponding to a decrease in maternal immunity.A marked increase in the antibody response was seen at 16-week of age, at the approximate time of onset of A. suis clinical signs in the herd.The evaluation of serum antibody responses to an autogenous vaccine revealed that the humoral immunity of gilts further increased following vaccination although the level of antibodies was already high prior to vaccination.The magnitude of the response to vaccination was higher when the level of antibodies was low prior to the first injection.The ELISA test seems to detect antibodies against the O-chain LPS. Actinobacillus suis / autogenous vaccine / ELISA / serologic profile / pigRésumé -Profil sérologique chez une cohorte de porcs et réponse humorale à un autovaccin pour Actinobacillus suis.Actinobacillus suis est généralement considéré comme un agent pathogène opportuniste chez le porc.Toutefois, en Amérique du Nord, une augmentation de la prévalence des signes cliniques associés à A. suis a été notée récemment dans des troupeaux de haut statut sanitaire.Les objectifs de cette étude étaient d'évaluer la cinétique des anticorps chez des porcs provenant Vet.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".