Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction
Bibliographic record
Abstract
Little is known concerning the contributions of oxidative phosphorylation (OxPhos), anaerobic glycolytic rate (AnGly), maximum creatine kinase (CK) activity, and metabolic economy (ME) on fatigue resistance. The purpose of this study was to model fatigue using muscle tissue metabolic measures during a maximal short-duration isometric contraction. Muscle metabolic function was measured with [31P]-magnetic resonance spectroscopy (MRS) in 54 premenopausal women (age: 33.8+/-6.3 y) while they performed 100% isometric plantar flexions. Multiple regression analysis revealed that all metabolic variables were independent predictors of fatigue resistance after adjusting for maximum isometric force generated (R2=0.56). ME accounted for the largest portion (36%) of overall shared variance. OxPhos accounted for the most shared variance of the three energy systems. These results support previous findings that OxPhos, AnGly, CK, and ME all contribute to fatigue resistance over a short duration. Additionally, the continued activity of CK at the end of 90 s of maximal exercise lends support to the concept of a CK shuttle facilitating energy transfer within the mitochondria.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".